These studies add to a growing body of

2018-10-20

These studies add to a growing body of information related to the role of p38 MAPK signaling in skeletal muscle progenitor cells. Over a decade ago, a requirement for p38 in the regulation of rodent myoblast differentiation was defined (Cuenda and Cohen, 1999; Zetser et al., 1999). Based on these pr

br Results br Discussion Many small molecules including two

2018-10-20

Results Discussion Many small molecules, including two reported by our group (Lee et al., 2013b), have been suggested to be selectively toxic to PSCs. However, as described previously (Knoepfler, 2009), despite the high potency and efficacy of small molecules that target hPSC-specific genes (e

Over the last few years gene editing by homologous

2018-10-20

Over the last few years, gene editing by homologous recombination (HR) has been widely used in human alizarin to avoid undesirable transgene insertion. HR efficacy is very limited in human cells, estimated at one HR event per 106 cells; however, the potential application of HR in human cells has be

br Results br Discussion Pluripotent stem cells

2018-10-20

Results Discussion Pluripotent stem csf-1r offer unprecedented potential for regenerative medicine as they can be differentiated by a specific sequence of signals to become any cell type of the body. At the same time, any cell product generated from them confers a substantial risk for neoplas

Introduction The correct functioning of the

2018-10-20

Introduction The correct functioning of the epigenome ensures fidelity in the establishment of gene-expression programs that are compatible with specific cell identities. The need for tightly controlled epigenetic landscapes is of critical importance for stem cells, which are able to both self-rene

br Results br Discussion In the present

2018-10-20

Results Discussion In the present study we show that LPA1 is expressed by stem and progenitor Elesclomol (predominantly type 1 and type 2a) within the neurogenic niche of the dentate gyrus of adult mice, and that it outperforms Nestin, the current gold standard, as a marker for prospective is

Finally we tested whether the B cell differentiation defect

2018-10-20

Finally, we tested whether the B cell differentiation defect in the OsxCre;iDTR mutants could be rescued in vivo by intravenous administration of recombinant IL-7 and IGF-1. Both controls and mutants were subjected to daily injections of DT, DT + IL-7, or DT + IGF-1 for 12 days. At the end of the re

br Introduction Newborn neurons are continuously generated t

2018-10-20

Introduction Newborn neurons are continuously generated throughout life in several areas of the mammalian brain, including the subgranular zone (SGZ) of the hippocampal dentate gyrus (Imayoshi et al., 2008; Palmer et al., 1997; Zhao et al., 2008). Adult hippocampal neurogenesis is essential for n

IGF and PI K signaling

2018-10-20

IGF and PI3K signaling in regenerating muscle was tightly regulated across multiple levels and temporally, especially during the transition between myoblast proliferation and differentiation. In the early period, IGF1 was upregulated and quickly followed by increases in expression and chromatin remo

Here we attempted to reprogram highly fluorescence activated

2018-10-20

Here, we attempted to reprogram highly fluorescence-activated cell sorting (FACS)-purified (100% purity) leukemia blasts from three subtypes of B-ALL, t(4;11)/MLL-AF4+, t(1;11)+MLL-EPS15+, and t(12;21)/ETV6-RUNX1 B-ALL, to establish novel iPSC-based disease models to address the developmental impact

Hello world!

2018-07-29