• Finally we demonstrate here that PML

  2018-10-24

  

  Finally, we demonstrate here that PML promotes iPSC generation by facilitating the early activation steps. Our proposed model for its contribution to reprogramming is that PML activates mesenchymal marker activation (EMT), which in turn enhances epithelial (MET) and pluripotent gene activation, res

• Acknowledging these and other concerns in the International

  2018-10-24

  

  Acknowledging these and other concerns, in 2016 the International Society for Stem Cell Research (ISSCR) updated its 2006 Guidelines for the Conduct of Human Embryonic Stem Cell Research and its 2008 Guidelines for Clinical Translation of Stem Cells to develop a comprehensive guidance document for s

• Scanners with LIDE LED indirect exposure are

  2018-10-24

  

  Scanners with LIDE (LED indirect exposure) are an improved version of the CIS technology. Here the light source uses powerful tri-color RGB (Red, Green, Blue) LEDs, and the radiation is directed to the object via quartz fibers ensuring uniform exposure over the entire width of the original scanner w

• br Results The study population that is included is

  2018-10-24

  

  Results The study population that is included is fairly similar to the entire Swedish population born 1934 to 1959 (Table 1). Those who were excluded from the analyses were more likely to be born at the beginning of the period and lack information on the variables of interest, or to be born at th

• Wicksell picked up the discussion of the effects

  2018-10-23

  

  Wicksell picked up the discussion of the effects of technical progress on distribution from where he had left it in 1890. Wicksell (1890, p. 257, n. 1) had complained that “any fully satisfactory and comprehensive treatment of the problem, once discussed in such a lively manner, of machinery\'s bene

• The major drawback of ARTs is

  2018-10-23

  

  The major drawback of ARTs is the potential of malaria parasites to escape from treatment after a few days, favoring the selection of drug-resistant parasites. This is the reason of the introduction of artemisinin-based combined therapies (ACTs) to treat malaria. These treatments are based on the as

• natural aromatase inhibitors In vitro high concentrations of

  2018-10-23

  

  In vitro, high concentrations of palmitate, glucose, or both combined cause beta cell endoplasmic reticulum (ER) stress and apoptosis. Beta cell ER stress is a known feature of type 2 diabetes in humans and animal models (). Cells respond to ER stress by activating the unfolded protein response (UPR

• Convincing vaccine hesitant patients to be vaccinated requir

  2018-10-23

  

  Convincing vaccine-hesitant patients to be vaccinated requires a response to GPs\' VH. Necessary steps include both better training and updating of GPs\' knowledge of vaccines\' benefits and risks: more time must be devoted to thymidine phosphorylase inhibitor during medical studies than is current

• This hypothesis also provides some insight into more

  2018-10-23

  

  This grams to moles calculator also provides some insight into more pronounced beneficial effects of low alcohol consumption on the risk of AP in women compared to men. Specifically, women are more likely to develop biliary problems and gallstones (Shen et al., 2013; Russell et al., 1998) and there

• br Materials Methods br Results br Discussion

  2018-10-23

  

  Materials & Methods Results Discussion We have used a partial DNA2 protein structure based on the homology between the helicase domain of DNA2 and yeast Upf1–RNA U15 complex and human Upf1–ADP complex (Chakrabarti et al., 2011; Cheng et al., 2007) to identify 3 well defined pockets (Sites 1

• To measure the presence of a wide range of pathogens

  2018-10-23

  

  To measure the presence of a wide range of pathogens directly from blood samples we leveraged a recently developed engineered version of the natural human blood opsonin, Mannose Binding Lectin, as a broad-spectrum agent that can capture a wide range of pathogens and released toxins. This engineered

• Dysfunction of the circadian clocks

  2018-10-23

  

  Dysfunction of the circadian clocks plays a role in mood disorders (). It is not known, however, whether they have a causal role in the etiology or display their effects on mood later during the pathogenesis. Basic research findings from mice recently pointed out that circadian rhythm abnormalities

• Fourth our findings could impact

  2018-10-23

  

  Fourth, our findings could impact the most widely used pharmacokinetic models of maturation as commonly recommended by regulatory authorities (European Medicines Agency, 2007). Several methods are used to examine the effect of maturation on pharmacokinetic parameters, with the two most common being

• The data from this study make

  2018-10-23

  

  The data from this study make important contributions to our knowledge of immune responses to Zika virus and to the development of effective vaccines against Zika. The authors utilized purified E protein, which was characterized by low protein yields, indicating that prM protein may be required for

• We hypothesize that filtration is

  2018-10-23

  

  We hypothesize that filtration is also causing stripping of merozoite surface proteins. Recent work has shown that merozoites can recruit the soluble complement regulator factor H (). We are concerned that filtration could also strip factor H or other complement regulators off merozoites making them

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