• The critical role of Bmi in tumorigenesis has

  2018-10-29

  

  The critical role of Bmi1 in tumorigenesis has prompted investigations into genes upstream of this proto-oncogene. Several candidate genes have been reported to be upstream of Bmi1 in various cancer models. In neuroblastoma, MYCN and E2F-1 appears to be regulating Bmi1 Nilotinib (Ochiai et al., 2010

• br Conclusions The results of this study are significant for

  2018-10-29

  

  Conclusions The results of this study are significant for a deeper understanding of the cellular changes that take place during ex vivo expansion of BMSCs and ASCs, and appear to concur with current knowledge on the use of hypoxic environments and the occurrence of replicative senescence. Relevan

• br Results br Discussion TALEs are natural effector proteins

  2018-10-29

  

  Results Discussion TALEs are natural effector proteins secreted by Xanthomonas and Ralstonia bacteria. These proteins regulate gene expression in host plants and thus facilitate bacterial survival and colonization (Moscou and Bogdanove, 2009). TALE contains a DNA-binding domain consisting of 3

• Translational controls have a central role in the

  2018-10-29

  

  Translational controls have a central role in the regulation of stem cell biology. The importance of translational regulations has been reported in mouse embryonic stem cells, which display a considerable increase in mRNA levels and translation during their differentiation (Sampath et al., 2008). In

• A fourth challenge is that

  2018-10-26

  

  A fourth challenge is that the high level of regulatory variation across countries necessitates far-reaching forms of scientific self-governance, training and procedural adjustments in participating clinical trial sites (Rosemann, 2014b). A central reason for this is, that the existence of regulator

• br Results br Discussion We previously showed that metformin

  2018-10-26

  

  Results Discussion We previously showed that metformin treatment enhances murine adult neurogenesis in vivo without depleting the endogenous NPC pool (Wang et al., 2012). This finding has led to studies to repurpose metformin as a neuroregenerative agent to treat the injured or degenerating cl

• Zscan is sometimes considered as a

  2018-10-26

  

  Zscan4 is sometimes considered as a marker of highly pluripotent status, merely due to its expression at the two-cell stage during development (Cerulo et al., 2014). However, based on our observation, we would like to propose that the expression of Zscan4 is activated in response to telomere shorten

• Taken together these findings indicate

  2018-10-26

  

  Taken together, these findings indicate that basal-to-luminal differentiation can occur in prostate organogenesis, pathogenesis, and ex vivo assays, but rarely during normal tissue homeostasis. Thus, it has been unclear to what extent the plasticity of endogenous adult prostate basal dhpg in ex viv

• br Results br Discussion Yamanaka

  2018-10-26

  

  Results Discussion Yamanaka factors induce somatic cell reprogramming to iPSCs by promoting spatiotemporal expression of PSC-specific and metabolic genes. However, only a small fraction of these propyl complete full reprogramming, leaving most cells at an intermediate stage (Chan et al., 2009

• We have previously shown that PRDM is transiently expressed

  2018-10-26

  

  We have previously shown that PRDM14 is transiently expressed in the inner cell mass (ICM) of blastocysts at embryonic day 3.5 (E3.5) and reactivated in specifying PGCs at approximately E6.25 (Yamaji et al., 2008). Knockout (KO) studies have demonstrated that expression of Prdm14 in the ICM is requi

• br Experimental Procedures br Author

  2018-10-26

  

  Experimental Procedures Author Contributions Acknowledgments This study was supported by the UCR Initial Complement Fund and the UCR Stem Cell Core Facility, funded by CIRM. Introduction Since the advent of cellular reprogramming with exogenous transcription factors (Takahashi et al., 2

• Both CSps and CDCs express endoglin also

  2018-10-26

  

  Both CSps and CDCs express endoglin (also known as CD105), considered a characteristic cell-surface marker of these chk1 (Smith et al., 2007). Endoglin is a membrane co-receptor for specific members of the transforming growth factor β (TGFβ) family of cytokines that regulate many aspects of cell fun

• br Author Contributions br Acknowledgments We thank

  2018-10-26

  

  Author Contributions Acknowledgments We thank members of the Surani lab and Dr Harry Leitch for critical reading of the manuscript and helpful discussions on the project. The Sox1-GFP ESCs were a kind gift from Prof. Austin Smith. The 2C::tdTomato construct was a kind gift from Dr Todd Macfarl

• The present work reports for

  2018-10-26

  

  The present work reports for the first time the synthesis of Ca5(PO4)3Cl:Eu2+ phosphor via the Pechini (citrate gel) method and the investigation of its photoluminescent properties. Experimental For synthesis of Eu2+ activated chlorapatite phosphor Ca5(PO4)3Cl stoichiometric amount of the precur

• The two models give different patterns of the ionic

  2018-10-26

  

  The two models give different patterns of the ionic displacements in the phonon branches. In the case of the rigid-ion model the fit indicates that the TA branch in the (q, q, 0) direction, for q >0.1, corresponds mainly to the motion of lead and hafnium with the lead displacements about 2 times lar

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